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Related Experiment Videos

Submucosal gastric cancer with lymph node metastasis

M Morita1, H Baba, T Fukuda

  • 1Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Journal of Surgical Oncology
|June 4, 1998
PubMed
Summary

Submucosal gastric cancer with larger size and invasion indicates higher lymph node metastasis risk. Patients with node-positive cancer require strict follow-up for lymphatic and hematogenic recurrence within five years post-gastrectomy.

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Area of Science:

  • Gastroenterology
  • Surgical Oncology
  • Pathology

Background:

  • Intraoperative assessment of lymph node metastasis in gastric cancer is challenging.
  • Recurrence patterns after gastrectomy for submucosal gastric cancer are not well understood.

Purpose of the Study:

  • To compare clinicopathologic features and recurrence patterns in submucosal gastric cancer based on lymph node metastasis status.
  • To identify risk factors for lymph node metastasis and recurrence.

Main Methods:

  • Retrospective analysis of 452 patients with submucosal gastric cancer.
  • Comparison of clinicopathologic features and recurrence patterns between node-positive (Group I, n=71) and node-negative (Group II, n=381) groups.

Main Results:

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  • Node-positive tumors were larger with significantly higher rates of lymphatic and vascular invasion.
  • Overall recurrence rate was 4.6%, with hematogenic recurrence most frequent (2.0%).
  • Lymphatic recurrence was significantly more common in node-positive patients (7.0% vs. 0.3%).

Conclusions:

  • Larger tumor size, lymphatic invasion, and vascular invasion are associated with high risk of lymph node metastasis in submucosal gastric cancer.
  • Close surveillance for lymphatic and hematogenic recurrence is crucial for node-positive patients, particularly within five years post-surgery.