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Related Experiment Video

Updated: Jul 20, 2026

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Ginkgo biloba for antidepressant-induced sexual dysfunction

A J Cohen1, B Bartlik

  • 1University of California, San Francisco, California, USA.

Journal of Sex & Marital Therapy
|June 5, 1998
PubMed
Summary

Ginkgo biloba effectively treated antidepressant-induced sexual dysfunction in 84% of participants. This herbal supplement positively impacted all sexual response phases, with women showing greater responsiveness than men.

Area of Science:

  • Pharmacology
  • Herbal Medicine
  • Sexual Health

Background:

  • Antidepressant medications, particularly selective serotonin reuptake inhibitors (SSRIs), frequently cause sexual dysfunction.
  • Ginkgo biloba, known for cognitive enhancement, was observed to improve erectile function in a geriatric patient.
  • Sexual dysfunction is a common and distressing side effect of various antidepressant classes.

Purpose of the Study:

  • To evaluate the efficacy of Ginkgo biloba in treating antidepressant-induced sexual dysfunction.
  • To assess the impact of Ginkgo biloba across all phases of the sexual response cycle.
  • To compare the effectiveness of Ginkgo biloba between genders for sexual dysfunction.

Main Methods:

  • An open-label trial involving 63 participants with antidepressant-induced sexual dysfunction.

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  • Participants received varying dosages of Ginkgo biloba extract (average 209mg/d).
  • Data collected on sexual function across desire, excitement, orgasm, and resolution phases.

    • Main Results:

    • Ginkgo biloba demonstrated an 84% overall effectiveness rate in treating sexual dysfunction.
    • Women (91% success rate) responded better than men (76% success rate).
    • Positive effects were observed across all four phases of the sexual response cycle.

    Conclusions:

    • Ginkgo biloba is a promising treatment for antidepressant-induced sexual dysfunction.
    • The herb positively influences multiple aspects of sexual function.
    • Further research into its mechanisms, including effects on neurotransmitters and vasodilation, is warranted.