Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transforming growth factor-beta (TGF-beta)

D A Clark1, R Coker

  • 1Department of Medicine, Pathology, Obstetrics and Gynecology, McMaster University, Hamilton, Ont., Canada. clarkd@csu.fhs.mcmaster.ca

The International Journal of Biochemistry & Cell Biology
|June 5, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The health department and medical care; group practice in preventive medicine.

American journal of public health and the nation's health·2010
Same author

The prognosis of fasciectomy for abductor digiti minimi and pretendinous cords in Dupuytren's disease of the little finger.

Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand·2010
Same author

Effects of reduced frequency of milk removal on gene expression in the bovine mammary gland.

Physiological genomics·2009
Same author

DISCUSSION ON THE TREATMENT BY PHYSICAL METHODS OF MEDICAL DISABILITIES INDUCED BY THE WAR.

Proceedings of the Royal Society of Medicine·2009
Same author

Effect of using a stand-off pad on Campylobacter jejuni strain diversity in a herd of dairy cows.

Letters in applied microbiology·2009
Same author

Humoral immune response to EBV in multiple sclerosis is associated with disease activity on MRI.

Neurology·2009
Same journal

Corrigendum to "Sodium butyrate down-regulation of indoleamine 2, 3-dioxygenase at the transcriptional and post-transcriptional levels" [Int. J. Biochem. Cell Biol. 42 (2010) 1840-1846].

The international journal of biochemistry & cell biology·2026
Same journal

Whole-brain spatial metabolomics reveals metabolic gradient shifts in a murine glioma model following boron neutron capture therapy (130 characters).

The international journal of biochemistry & cell biology·2026
Same journal

LCN2 modulates Th17/Treg balance in vitro and is associated with an adaptive response to intestinal ischemia-reperfusion injury under Hmox1-deficient conditions.

The international journal of biochemistry & cell biology·2026
Same journal

Chloroquine modulates the redox-sensitive signalling via inhibiting the AMPK-ULK1 under LPS induced state in murine splenic macrophages.

The international journal of biochemistry & cell biology·2026
Same journal

The vicious cycle of hyperglycemia and oxidative stress: Novel mechanistic insights into a pathogenic alliance.

The international journal of biochemistry & cell biology·2026
Same journal

Fibroblast growth factors (FGF) in the pathogenesis and treatment of inflammatory bowel diseases (IBD): An overview.

The international journal of biochemistry & cell biology·2026
See all related articles

The Transforming Growth Factor-beta (TGF-beta) cytokine family is vital for survival, regulating growth, immunity, and inflammation. Gene knockout studies highlight its essential role, with implications for treating inflammatory and fibrotic diseases.

Area of Science:

  • Cell Biology
  • Immunology
  • Developmental Biology

Background:

  • The Transforming Growth Factor-beta (TGF-beta) cytokine superfamily is crucial for numerous physiological processes.
  • These cytokines are involved in cell growth, development, immune responses, and tissue repair.
  • TGF-beta isoforms are secreted as latent precursors and interact with cell surface receptors to mediate signaling.

Purpose of the Study:

  • To review the multifaceted roles of the TGF-beta cytokine family.
  • To highlight the significance of TGF-beta in both normal physiological functions and disease pathogenesis.
  • To explore the potential diagnostic and therapeutic applications of TGF-beta in inflammatory and fibrotic conditions.

Main Methods:

  • Literature review of existing studies on TGF-beta.

Related Experiment Videos

  • Analysis of gene knockout mouse models to understand TGF-beta function.
  • Examination of novel TGF-beta-like molecules.

    • Main Results:

    • TGF-beta 1 gene knockout mice exhibit severe developmental defects and uncontrolled inflammation, underscoring its essential role.
    • TGF-beta isoforms (1, 2, and 3) are critical for survival and proper development.
    • Novel TGF-beta-like molecules with shared properties have been identified.

    Conclusions:

    • The TGF-beta family plays indispensable roles in maintaining homeostasis and in disease.
    • Dysregulation of TGF-beta signaling is implicated in various pathological conditions, including inflammation and fibrosis.
    • Targeting TGF-beta pathways offers promising avenues for diagnosing and treating diseases characterized by inflammation and fibrosis.