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New 4-thiazoline-2-hydrazono-1H-2-indolinones as possible antimicrobial agents
N Karali1, N Terzioglu, A Gürsoy
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Istanbul, Turkey.
Bollettino Chimico Farmaceutico
|June 5, 1998
Abstract:
In order to test their antimicrobial activity a series of new 3-[(3-substituted-4-methyl-5-carboxy/carbetoxy-4-thiazolin-2 - ylidene)hydrazono]-1H-2-indolinones (3a-i/4) were synthesized from the reaction of 3-(4-substituted-3-thiosemicarbazono-1H-2-indolinones (1a-I) with 2-chloroacetoacetic acid ethyl ester (2). All synthesized compounds were characterized by IR, 1H-NMR, EIMS and elementary analysis.