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[Recurrent infection by Streptococcus agalactiae]

M T García1, T Juncosa, Y Jordán

  • 1Servicio de Pediatría, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona.

Enfermedades Infecciosas Y Microbiologia Clinica
|June 5, 1998
PubMed
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Early newborn sepsis caused by Streptococcus agalactiae can relapse. This study found the same bacterial clone and ampicillin tolerance in a recurrent infection, highlighting the need for careful antibiotic selection.

Area of Science:

  • Neonatal infectious diseases
  • Microbiology
  • Pharmacology

Background:

  • Neonatal early sepsis is a serious concern.
  • Streptococcus agalactiae (Group B Strep) is a common cause of neonatal infections.
  • Recurrent infections pose significant treatment challenges.

Observation:

  • Two episodes of sepsis by S. agalactiae occurred in the same newborn, with relapse at five days post-discharge.
  • The isolated S. agalactiae strains were analyzed using genomic macrorestriction for typing.
  • Antibiotic tolerance was assessed using timed killing curves.

Findings:

  • Both S. agalactiae strains isolated from the patient belonged to the same clone (type la/c).
  • The S. agalactiae strain exhibited tolerance to ampicillin.

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Implications:

  • Neonatal sepsis due to S. agalactiae can recur, emphasizing the severity of these infections.
  • Understanding the specific bacterial clone and its antibiotic susceptibility is crucial for effective treatment.
  • Tailoring antibiotic regimens based on microbial characteristics can help prevent relapses in neonatal sepsis.