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[Recurrent infection by Streptococcus agalactiae]
M T García1, T Juncosa, Y Jordán
1Servicio de Pediatría, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona.
Background:
To study the factors implicated in the infectious process (host, microorganism and antibiotic) of a newborn early sepsis by S. agalactiae that suffered a reactivation at day five from discharge.
Methods:
Description of two episodes of newborn sepsis by S. agalactiae corresponding to the same patient and microbiologic study of the isolated strain: typing by "genomic macrorestriction" and antibiotic tolerance by "timed killing curves".
Results:
It was demonstrated that both strains of S. agalactiae type la/c belonged to the same clone as well as the tolerance to ampicillin of the strain.
Discussion:
This sort of infections processes in the newborn are very serious and there is possibility of relapse. Thus, it is important to study the ethiologic agent and its relationship with antibiotics, in order to stablish the best treatment regimes, avoiding the possibility of relapses as the case we have described.
Insights
Early newborn sepsis caused by Streptococcus agalactiae can relapse. This study found the same bacterial clone and ampicillin tolerance in a recurrent infection, highlighting the need for careful antibiotic selection.
Area of Science:
- Neonatal infectious diseases
- Microbiology
- Pharmacology
Background:
- Neonatal early sepsis is a serious concern.
- Streptococcus agalactiae (Group B Strep) is a common cause of neonatal infections.
- Recurrent infections pose significant treatment challenges.
Observation:
- Two episodes of sepsis by S. agalactiae occurred in the same newborn, with relapse at five days post-discharge.
- The isolated S. agalactiae strains were analyzed using genomic macrorestriction for typing.
- Antibiotic tolerance was assessed using timed killing curves.
Findings:
- Both S. agalactiae strains isolated from the patient belonged to the same clone (type la/c).
- The S. agalactiae strain exhibited tolerance to ampicillin.
Implications:
- Neonatal sepsis due to S. agalactiae can recur, emphasizing the severity of these infections.
- Understanding the specific bacterial clone and its antibiotic susceptibility is crucial for effective treatment.
- Tailoring antibiotic regimens based on microbial characteristics can help prevent relapses in neonatal sepsis.