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Published on: September 25, 2019
Clinical predictors of cardiac complications in patients with acute ischemic brain disease
R Raicević1, A Jovicic, D Tavcioski
1Military Medical Academy, Clinic of Neurology, Belgrade.
Insights
Age and the side of a neurological incident are key predictors of cardiac complications like ST depression in patients with acute ischemic brain disease. These factors also show a borderline predictive value for ventricular arrhythmias.
Area of Science:
- Neurology
- Cardiology
- Vascular Medicine
Background:
- Heart and brain vascular diseases are leading causes of death globally.
- Cardiac complications can arise during the development of brain ischemia.
- Identifying predictors of cardiac events in acute ischemic brain disease (AIBD) is crucial.
Purpose of the Study:
- To identify clinical predictors of cardiac complications in patients with AIBD.
- To assess specific electrocardiographic changes as potential predictors.
- To evaluate the role of age and neurological incident characteristics.
Main Methods:
- Study included 40 patients with AIBD and no prior coronary disease history.
- 24-hour Holter monitoring was performed within 48 hours of AIBD onset.
- Computerized ECG analysis and interpretation by a cardiologist.
Main Results:
- Age and the side of the neurological incident were significant independent predictors of ST depression.
- These factors also indicated simultaneous heart ischemia.
- The same parameters showed borderline predictive value for ventricular arrhythmias (VA).
Conclusions:
- Age and neurological incident lateralization are important predictors for ST depression and heart ischemia in AIBD patients.
- These factors may have a limited role in predicting ventricular arrhythmias.
- Further research is warranted to fully understand cardiac complication predictors in AIBD.
Abstract:
Heart and brain vascular diseases present leading causes of death in civilized world. During development of brain ischemia cardiac complications are possible. The aim of this study was to determine the existence of cardiac complications' clinical predictors by assessing certain electrocardiographic changes in patients with acute ischemic brain disease (AIBD). Forty patients with AIBD, without previous coronary disease history were included in the study. All patients underwent 24 hour Holter monitoring during first 48 hours after the onset of AIBD which was diagnosed by computerized brain tomography. ECG-s were analyzed by computer and interpreted by the same cardiologist. Independent variables in statistical analyses were: age, AIBD, cardiological therapy atherosclerosis risk factors, heart disease history, degree of severity and lateralization of neurological incident and maximal arterial blood pressure values. Dependent variables were: presence/absence of ST depression and presence/absence of ventricular arrhythmias (VA). All parameters as well as their interreaction, were statistically analyzed. Results point that age and side of neurological incident present independent important predictive factors for appearance of ST depression, as well as simultaneous heart ischemia, while the same parameters have border value as predictive factors for VA.
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