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Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration
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TNF-alpha inhibits liver collagen-alpha 1(I) gene expression through a tissue-specific regulatory region

K Houglum1, M Buck, D J Kim

  • 1Department of Medicine, Veterans Affairs Medical Center, San Diego, California, USA.

The American Journal of Physiology
|June 5, 1998
PubMed

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Cell Specific Gene Expression

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NF-κB-dependent Signaling Pathway

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General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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TGF - β Signaling Pathway

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Transducer Mechanism: Nuclear Receptors

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