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[Structural and functional characteristics of angiotensin converting enzyme]
1Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, Russia.
Bioorganicheskaia Khimiia
|June 5, 1998
Abstract:
The structure and functions in various tissues of angiotensin converting enzyme (ACE, peptidyl dipeptidase A), a key enzyme in blood pressure regulation, are reviewed. The similarity and differences of two homologous catalytically active N- and C-domains of the ACE molecule are discussed, and different biological functions of these domains are suggested. Natural active single-domain forms of ACE are characterized.