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[Cloning and structure-function analysis of the human S26 ribosomal protein gene]
M L Filipenko1, N A Vinichenko, G G Karpova
1Novosibirsk Institute of Bioorganic Chemistry, Russian Academy of Sciences, Russia.
Genetika
|June 5, 1998
Abstract:
Gene HRPS26 encoding the S26 human ribosomal protein has been sequenced. Gene HRPS26 consists of four exons and three introns. Its size is 2027 bp; the size of its mRNA is 438 nucleotides. As most of the genes of ribosomal proteins of vertebrates, the HRPS26 gene has a short first exon, which corresponds to the 5'-untranslated region of mRNA; the origin of transcription is located in the polypyrimidine tract. The functional activity of the cloned HRPS26 promoter region has been confirmed by transcription of hybrid plasmids in HeLa cells.