[Does desensitisation of acetylcholine receptors play a physiological role in the neuromuscular synapse?]

After the acetylcholinesterase inhibition, desensitisation of neuro-muscular junctions was found to limit rebundunt activity of postsynaptic membranes and disturb normal transmission. Long-term densensitisation of cholinoreceptors entails shortening of the postsynaptic current decay due, probably, to a high affinity binding the acetylcholine molecules to the desensitised receptors. This may prevent repetitive interactions with active receptors and buffer a certain amount of acetylcholine.