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MR of cerebral malaria
Y S Cordoliani1, J L Sarrazin, D Felten
1Department of Radiology, Val-de-Grâce Armed Forces Hospital, Paris, France.
AJNR. American Journal of Neuroradiology
|June 5, 1998
Summary
Magnetic Resonance (MR) imaging revealed white matter abnormalities and cortical infarcts in cerebral malaria cases. These findings highlight potential neuroimaging markers for this severe disease.
Area of Science:
- Neurology
- Radiology
- Infectious Diseases
Background:
- Cerebral malaria is a severe neurological complication of Plasmodium falciparum infection.
- Neuroimaging plays a crucial role in understanding the pathophysiology of cerebral malaria.
Observation:
- Three cases of cerebral malaria underwent MR imaging.
- Specific sequences like T2-weighted and fluid-attenuated inversion-recovery (FLAIR) were utilized.
Findings:
- MR imaging identified cortical infarcts in one case.
- Two cases exhibited white matter abnormalities, including sharply limited, symmetrical, hyperintense lesions and diffuse hyperintensity.
- Diffuse hyperintensity was attributed to edema, while focal lesions suggested gliosis.
Implications:
- These neuroimaging findings can aid in diagnosing and understanding the neurological damage in cerebral malaria.
- Identifying specific patterns of white matter abnormalities may correlate with disease severity and prognosis.