Polyunsaturated fatty acid regulation of gene expression

For the past three decades, polyunsaturated fatty acids (PUFA) have been recognized as important energy sources and membrane components. PUFA also play key roles in many cellular events, such as gene regulation. Most recently, research has focused on identifying the mechanisms by which PUFA modulate gene transcription, mRNA stability and cellular differentiation. It is the purpose of this review to examine the effects of PUFA on gene expression in lipogenic as well as other tissues. Because the (n-3) and (n-6) series of PUFA are intimately involved in gene regulation, they will be the focus of review. The effects of other fatty acid families on gene expression are reviewed elsewhere.