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Psychostimulant augmentation of second generation antidepressants: a case series
P S Masand1, V S Anand, J F Tanquary
1Department of Psychiatry, SUNY Health Science Center at Syracuse 13210, USA.
Objective:
The authors attempted to treat Major Depressive Disorder (MDD) suboptimally responsive to one of the newer (second-generation) antidepressants by augmentation with a psychostimulant medication.
Method:
Seven cases of MDD showing a partial response to an adequate trial of a second generation antidepressant were augmented with a psychostimulant.
Results:
A marked improvement in clinical symptoms of depression was noted in all cases, with particular improvement in apathy and feelings of fatigue.
Conclusion:
Psychostimulant augmentation of the newer generation antidepressants is a promising new strategy. Further controlled investigation is warranted to explore various aspect of this method.