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Evolutionary analysis of RNA editing enzymes
1Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA.
Methods (San Diego, Calif.)
|June 6, 1998
Abstract:
This article focuses on the evolution of apolipoprotein B (apoB) mRNA editing. We review the tools commonly used in homology search and phylogenetic analysis and demonstrate their use in the analysis of RNA-editing enzymes. The ultimate goal is to apply these tools to answer two questions: How did apoB mRNA editing come about? How might it be related to other base substitution editing in the course of evolution.