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X-ray studies of enzymes that interact with penicillins
J A Kelly1, A P Kuzin, P Charlier
1Department of Molecular and Cell Biology, University of Connecticut, Storrs, USA.
Cellular and Molecular Life Sciences : CMLS
|June 6, 1998
Abstract:
The technique of X-ray diffraction has been successfully applied to enzymes associated with peptidoglycan biosynthesis. The technique has taught us a great deal about the structures and catalytic mechanisms of penicillin-binding proteins and beta-lactamases. An insight into the structural basis for antibiotic resistance is given.