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The efficacy of hyperthermia combined with radiation therapy for high-grade soft tissue sarcoma
H Nakano1, S Higaki, A Tateishi
1Department of Orthopaedic Surgery, Teikyo University School of Medicine, Tokyo, Japan.
Background:
We have investigated the efficacy of preoperative hyperthermia combined with radiation therapy (HIRP) in cases of soft tissue sarcoma (STS) that could be consequently treated with limb salvage.
Materials And Methods:
Thirteen patients with STS in an extremity received HIRP at our institution. Local hyperthermia for 1 hour was administered eight to ten times. Radiation therapy (40-60 Gy) was administered at 2 Gy per session. The operation was performed at 2 or 3 weeks after HIRP.
Results:
Limb salvage surgery was achieved in 12 patients. No local recurrence was observed during a mean follow-up of 27 months. 7 patients had shown only a partial response to the HIRP. There was no correlation between the histological response and the observed reduction in tumor volume.
Conclusions:
The results of this study suggested that HIRP was an effective local treatment for limb salvage in limb-threatening STS.