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Discovery of podophyllotoxins
1Division of Medicinal Chemistry, Centre de Recherche Pierre Fabre, Castres, France.
Biochimie
|June 6, 1998
Summary
This review highlights the discovery of lignan derivatives, like podophyllotoxin, for cancer chemotherapy. These compounds, including etoposide and teniposide, inhibit microtubule assembly and topoisomerase II, improving cancer treatment.
Area of Science:
- Natural Products Chemistry
- Medicinal Chemistry
- Oncology
Background:
- Lignan derivatives are crucial in cancer chemotherapy.
- Podophyllotoxin, a natural lignan, inhibits microtubule assembly.
- Etoposide and teniposide are clinically significant anticancer drugs derived from podophyllotoxin.