Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Ultrastructural changes in aspirin hepatotoxicity

T Iancu, E Elian

American Journal of Clinical Pathology

|September 1, 1976

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Advances in varicella immunization].

Harefuah·1991

Same author

[Johanson-Blizzard syndrome].

Harefuah·1988

Same author

Endophthalmitis due to Salmonella typhimurium.

Journal of pediatric ophthalmology and strabismus·1986

Same author

Nocturnal enuresis: a familial condition.

Journal of the Royal Society of Medicine·1984

Same author

Trigonocephaly: a new familial syndrome.

American journal of medical genetics·1984

Same author

Ultrastructural and functional studies of the platelets in patients with May-Hegglin anomaly.

Haematologica·1982

Same journal

Invasive urothelial carcinoma in association with surface low-grade papillary urothelial carcinoma: clinical and pathologic insights from a rare entity.

American journal of clinical pathology·2026

Same journal

CEACAM1 expression by immunohistochemistry in B-cell lymphomas and plasma cell myeloma.

American journal of clinical pathology·2026

Same journal

Comprehensive multicriteria life cycle assessment of biopsy processing in a surgical pathology department.

American journal of clinical pathology·2026

Same journal

Prognostic significance of Myb protein and its downstream target genes in lacrimal gland adenoid cystic carcinoma.

American journal of clinical pathology·2026

Same journal

Mismatch repair protein "nonclassic expression loss" pattern in colorectal cancer: an important staining pattern that is not well understood.

American journal of clinical pathology·2026

Same journal

Musculoskeletal pain in medical laboratory personnel: a cross-sectional study.

American journal of clinical pathology·2026

See all related articles

Aspirin may harm the liver, especially in children. This study observed liver cell damage in a boy treated with aspirin, suggesting careful monitoring of liver enzymes during treatment is crucial.

Area of Science:

Hepatology
Pediatric Medicine
Toxicology

Background:

Rheumatic fever treatment often involves aspirin.
Elevated serum transaminase levels can indicate liver injury.
Hepatotoxicity is a potential adverse effect of drug therapy.

Observation:

A 9-year-old boy on aspirin for rheumatic fever presented with elevated transaminases.
Percutaneous liver biopsy revealed significant hepatocyte fine-structure changes.
Changes included endoplasmic reticulum dilation/proliferation and mitochondrial abnormalities.

Findings:

The observed ultrastructural changes in hepatocytes are consistent with drug-induced hepatotoxicity.
Aspirin demonstrated potential hepatotoxic effects at the cellular level.

Related Experiment Videos

Morphological evidence supports aspirin's role in liver injury.

Implications:

These findings highlight the importance of monitoring liver function in patients receiving aspirin.
Regular transaminase measurements are recommended for patients on systemic aspirin therapy.
Further research into aspirin's hepatotoxicity in pediatric populations is warranted.