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Updated: Aug 18, 2026

Assessing Biofilm Dispersal in Murine Wounds
Published on: August 7, 2021
Metrotop: a topical antimicrobial agent for malodorous wounds
1Salisbury Healthcare NHS Trust.
Abstract:
The eradication of pungent wound odour is one of the most challenging problems for health professionals involved in wound management. The presence of malodour can cause immeasurable distress for the patient and his/her family, making many sufferers' lives one of self-imposed exile. Clinical research using topical metronidazole over the past 20 years clearly indicates that metronidazole is effective against the anaerobic bacteria that cause these foul and distressing odours. Seton Healthcare produces a commercial preparation called Metrotop--a topical metronidazole gel which is available on prescription.
Insights
Topical metronidazole effectively combats pungent wound odor by targeting anaerobic bacteria. This treatment significantly improves patient quality of life by reducing distress associated with malodor.
Area of Science:
- Wound Management
- Microbiology
- Dermatology
Background:
- Pungent wound odor presents a significant challenge in patient care.
- Malodor causes severe distress, impacting patients' social and emotional well-being.
- Anaerobic bacteria are the primary cause of distressing wound odors.
Purpose of the Study:
- To highlight the efficacy of topical metronidazole in managing wound odor.
- To provide an overview of metronidazole's role in wound care.
- To introduce Metrotop, a prescription topical metronidazole gel.
Main Methods:
- Review of clinical research on topical metronidazole over 20 years.
- Focus on metronidazole's antimicrobial properties against anaerobic bacteria.
- Identification of commercial preparations like Metrotop.
Main Results:
- Metronidazole is clinically proven effective against odor-causing anaerobic bacteria.
- Topical application of metronidazole addresses wound malodor directly.
- Established research supports metronidazole's role in wound odor management.
Conclusions:
- Topical metronidazole is a reliable treatment for pungent wound odor.
- Addressing wound odor improves patient quality of life.
- Metrotop offers a prescription-based solution for effective wound odor control.
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