Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Suicide: a four-pathway clinical-biochemical model

J Fawcett1, K A Busch, D Jacobs

  • 1Department of Psychiatry, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA. jfawcett@rush.edu

Annals of the New York Academy of Sciences
|June 9, 1998
PubMed
Summary

Four pathways to suicide in clinical depression are proposed: acute anxiety/agitation linked to high corticotrophin-releasing factor (CRF), chronic hopelessness, severe anhedonia, and impulsiveness associated with low serotonin and cholesterol. These factors offer targets for suicide prevention.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Autism spectrum disorder diagnosis in young children: a clinical-ethical study on the experiences of parents and physicians].

Tijdschrift voor psychiatrie·2021
Same author

Graphene oxide/waterborne polyurethane nanocoatings: effects of graphene oxide content on performance properties.

Journal of coatings technology and research·2020
Same author

Factors Influencing Longitudinal Stair Climb Performance from Midlife to Early Late Life: The Study of Women's Health Across the Nation Chicago and Michigan Sites.

The journal of nutrition, health & aging·2019
Same author

[Abdominal necrotizing fasciitis after caesarean delivery].

Revue medicale de Bruxelles·2017
Same author

Physiologic Responses to Treadmill and Water Running.

The Physician and sportsmedicine·2016
Same author

Plasma cholinesterase deficiency in Turkish patients.

Anaesthesia·2016

Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Psychology

Background:

  • Suicide remains a significant public health concern, particularly in individuals with clinical depression.
  • Understanding the underlying mechanisms of suicidal behavior is crucial for developing effective prevention and intervention strategies.

Purpose of the Study:

  • To propose four distinct hypothetical pathways contributing to suicide risk in clinical depression.
  • To synthesize current research linking biological and psychological factors to different suicide risk trajectories.

Main Methods:

  • Review of recent research and presented data.
  • Analysis of factors associated with acute and chronic suicide risk.
  • Examination of biological correlates such as corticotrophin-releasing factor (CRF), serotonin turnover, and cholesterol levels.

Related Experiment Videos

Main Results:

  • Four proposed pathways: 1) acute anxiety/agitation with high CRF, 2) trait hopelessness, 3) severe anhedonia, and 4) trait impulsiveness with low serotonin turnover and cholesterol.
  • Evidence suggests acute suicidal risk linked to anxiety/agitation and CRF may be reversible.
  • Chronic risk factors include hopelessness and anhedonia, while low cholesterol correlates with suicide in depressed inpatients.

Conclusions:

  • The identified pathways provide a framework for investigating the mechanisms of suicidal behavior in depression.
  • Further research into these pathways can inform the development of targeted interventions for suicide prevention.
  • Understanding the interplay of biological and psychological factors is key to addressing suicide risk.