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Updated: Aug 13, 2026

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
[Morphometric correlation at the experimental level of renogram with renal arterial stenosis]
L A Rodríguez Toves1, M V Fernández Esteban, J Calleja Escudero
1Laboratorios de Cirugía Experimental, Facultad de Medicina, Valladolid.
Rationale:
A reduction of the renal size seen with the nephrogram (intravenous urography) has been described in renal artery stenosis. Such reduction, however, has not been quantified and the evolution is unknown in terms of duration of stenosis evolution.
Methods:
Experimental study in rats which underwent controlled stenosis of a renal artery, with evaluation, using planimetry of the area and perimeter of the nephrogram, of the consequences such stenosis had at different observation intervals (30, 90 and 180 days). The effects of the stenosis relative to the duration of the experiment is also evaluated.
Results:
The area and perimeter of the nephrogram become reduced in kidneys with artery stenosis. Besides, this reduction increases over time.
Conclusion:
The area and perimeter of the nephrogram are a useful method to study renal artery stenosis in rats.
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