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Fibrillar crystal structure in essential monoclonal IgM kappa cryoglobulinemia
Y Tomiyoshi1, T Sakemi, Y Yoshikawa
1Department of Internal Medicine, Saga Medical School, Nabeshima, Japan.
Clinical Nephrology
|June 9, 1998
Abstract:
In monoclonal IgG cryoglobulinemia, two types of crystallization have been demonstrated with electron microscopy at high magnification. In contrast, little information is available on well-defined crystallization in cases of monoclonal IgM cryoglobulinemia. We present a case of pure monoclonal IgM kappa cryoglobulinemia and rapidly progressive glomerulonephritis occurring in a 75-year-old woman. We detected unequivocal formation of fibrillar crystal structure within intraglomerular macrophages on electron microscopy: the structure accords with that in a case of monoclonal IgG cyroglobulinemia described in the literature.