Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Risperidone compared with both lithium and haloperidol in mania: a double-blind randomized controlled trial

J Segal1, M Berk, S Brook

  • 1Department of Psychiatry, University of the Witwatersrand Medical School, Johannesburg, South Africa.

Clinical Neuropharmacology
|June 9, 1998
PubMed
Summary

Risperidone demonstrates equivalent efficacy to lithium and haloperidol for treating acute mania. This randomized trial found similar improvements in mania symptoms and side effect profiles across all treatments.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inflammation and late-life depressive symptoms.

medRxiv : the preprint server for health sciences·2026
Same author

Search for Light Pseudoscalar Bosons, Pair-Produced in Higgs Boson Decays in the Four-Electron Final State in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2026
Same author

Observation of Suppressed Charged-Particle Production in Ultrarelativistic Oxygen-Oxygen Collisions.

Physical review letters·2026
Same author

Measurement of D^{0} Meson Photoproduction in Ultraperipheral Heavy Ion Collisions.

Physical review letters·2026
Same author

Observation of tWZ Production at the CMS Experiment.

Physical review letters·2026
Same author

Family History and Solar Insolation in Bipolar I Disorder.

Acta psychiatrica Scandinavica·2026

Area of Science:

  • Psychiatry
  • Clinical Pharmacology

Background:

  • Previous case reports and studies indicated potential efficacy of risperidone in mania treatment.
  • Neuroleptics are a class of drugs used to manage psychosis and other symptoms.

Purpose of the Study:

  • To compare the efficacy and safety of risperidone, haloperidol, and lithium in treating acute mania.
  • To evaluate risperidone's effectiveness against established treatments for manic episodes.

Main Methods:

  • A 28-day randomized, controlled, double-blind trial involving 45 inpatients diagnosed with DSM-IV mania.
  • Participants received daily doses of risperidone (6 mg), haloperidol (10 mg), or lithium (800-1200 mg).
  • Efficacy was assessed using the Brief Psychiatric Rating Scale, Mania Rating Scale, Global Assessment of Functioning, and Clinical Global Impression.

Related Experiment Videos

Main Results:

  • All three treatment groups showed comparable improvement in total scores across all rating scales by day 28.
  • Statistical analysis (ANOVA) revealed no significant differences between lithium, haloperidol, and risperidone on the Brief Psychiatric Rating Scale (p=0.37) or Mania Rating Scale (p=0.35).
  • Similar patterns of improvement were observed in Global Assessment of Functioning and Clinical Global Impression scores; extrapyramidal side effects did not significantly differ between risperidone and haloperidol.

Conclusions:

  • Risperidone is an effective treatment for acute mania, showing efficacy comparable to lithium and haloperidol.
  • The study supports risperidone as a viable alternative for managing acute manic episodes.
  • No significant difference in extrapyramidal side effects was noted between risperidone and haloperidol.