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Related Experiment Videos

Increased intraocular pressure induced by corticosteroids

Y Kitazawa

    American Journal of Ophthalmology
    |September 1, 1976
    PubMed
    Summary
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    Topical corticosteroids like betamethasone can increase intraocular pressure (IOP) in a dose-dependent manner. Higher concentrations of betamethasone and other steroids showed a greater potential to elevate IOP in patients responsive to steroids.

    Area of Science:

    • Ophthalmology
    • Pharmacology

    Background:

    • Topical corticosteroids are widely used in ophthalmology.
    • Betamethasone is a potent corticosteroid with potential side effects, including elevated intraocular pressure (IOP).
    • Individual responses to corticosteroids can vary, necessitating further investigation into dose-response relationships.

    Purpose of the Study:

    • To compare the intraocular pressure elevating potential of various topical corticosteroid preparations.
    • To determine the dose-related effect of betamethasone on IOP in patients highly responsive to this steroid.
    • To establish an order of potency for different corticosteroids in terms of IOP elevation.

    Main Methods:

    • Twelve patients with a history of high responsiveness to topical betamethasone were enrolled.

    Related Experiment Videos

  • Each patient received four different corticosteroid preparations (fluorometholone, tetrahydrotriamcinolone, medrysone, and betamethasone) in the same eye.
  • Intraocular pressure was measured after four weeks of daily topical administration (four times daily).

    • Main Results:

    • A significant, dose-related correlation was observed between corticosteroid concentration and IOP elevation.
    • The order of potential to elevate IOP was: betamethasone 0.1% > betamethasone 0.05% > tetrahydrotriamcinolone 1.25% > betamethasone 0.02% > fluorometholone 0.1% > medrysone 1.0% > betamethasone 0.01%.
    • Lower concentrations of tetrahydrotriamcinolone (0.25%) and fluorometholone (0.05% and 0.01%) did not significantly elevate IOP.

    Conclusions:

    • The potential of topical corticosteroids to elevate intraocular pressure is concentration-dependent.
    • Betamethasone exhibits a strong dose-response relationship for IOP elevation.
    • Clinical use of topical corticosteroids requires careful consideration of drug concentration and individual patient response to mitigate risks like elevated IOP.