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Related Experiment Videos

Tissue response to covered Wallstents

B L Dolmatch1, Y H Dong, S O Trerotola

  • 1Department of Radiology, Cleveland Clinic Foundation, OH 44195, USA.

Journal of Vascular and Interventional Radiology : JVIR
|June 9, 1998
PubMed
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Polyethylene terephthalate interbraided Wallstents (PET-WSs) induced inflammation, unlike bare mesh Wallstents (WSs) or ePTFE-covered WSs. All stent-graft types showed excellent patency in this canine iliac artery model.

Area of Science:

  • Vascular surgery
  • Biomaterials science
  • Histopathology

Background:

  • Endoluminal stent-grafts are crucial in treating vascular diseases.
  • Understanding the biocompatibility and healing response of different stent-graft materials is essential for clinical success.

Purpose of the Study:

  • To compare the healing responses of bare mesh Wallstents (WSs), polyethylene terephthalate interbraided WSs (PET-WSs), and ePTFE-covered WSs in a canine iliac artery model.

Main Methods:

  • Three types of Wallstents (bare WS, PET-WS, ePTFE-WS) were implanted in 12 dogs' iliac arteries.
  • Arteriograms were taken pre-implantation, post-implantation, and at explantation.
  • Devices were explanted at 1, 3, and 6 months for histological analysis.

Main Results:

Related Experiment Videos

  • All implant types demonstrated excellent patency, with only one ePTFE-WS thrombosing.
  • Bare WS and ePTFE-WS showed uniform myointimal healing without inflammation.
  • PET-WS exhibited significant foreign body inflammation and a thicker neointimal response.

Conclusions:

  • Polyethylene terephthalate stent-grafts induced chronic inflammation, potentially explaining adverse events in human studies.
  • Bare mesh and ePTFE-covered Wallstents demonstrated favorable healing responses.
  • Excellent patency was observed across all tested stent-graft types in this model.