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[Histamine in the pathogenesis of asthma]
1Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan.
Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
|June 10, 1998
Summary
Histamine, a key allergy mediator, triggers asthma symptoms like bronchospasm and edema via H1 receptors. Its widespread effects on endothelial cells and cytokine release suggest a larger role in allergic inflammation than previously understood.
Area of Science:
- Immunology
- Allergy Research
Context:
- Histamine is a primary mediator in IgE-mediated allergic diseases.
- Asthma pathogenesis involves smooth muscle spasm, mucosal edema, inflammation, and mucus secretion.
Purpose:
- To re-examine the role of histamine in allergic inflammation, particularly in asthma.
- To explore histamine's effects on endothelial cells and its contribution to late-phase allergic reactions.
Summary:
- Histamine binding to H1 receptors causes bronchospasm and mucosal edema in asthma.
- Histamine induces endothelial cell permeability, P-selectin expression, and lipid mediator secretion.
- Histamine stimulates IL-6 and IL-8 release from endothelial cells, potentially driving late-phase reactions and recruiting inflammatory cells.
- Certain antihistamines can reduce intercellular adhesion molecule 1 (ICAM-1) expression.
Impact:
- Highlights histamine's extensive impact beyond early allergic responses.
- Suggests histamine's significant, underappreciated role in the complex mechanisms of allergic inflammation.
- Provides a basis for re-evaluating therapeutic strategies targeting histamine in allergic diseases like asthma.