Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Airway hypersecretion and mucociliary dysfunction in asthma]

J Tamaoki1

  • 1First Department of Medicine, Tokyo Women's Medical College, Japan.

Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
|June 10, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chloride ion transport and overexpression of TMEM16A in a guinea-pig asthma model.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2017
Same author

Inhibition of neutrophil elastase-induced goblet cell metaplasia by tiotropium in mice.

The European respiratory journal·2009
Same author

Role of epidermal growth factor receptor in maintaining airway goblet cell hyperplasia in rats sensitized to allergen.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2008
Same author

Interleukin-9 and Interleukin-13 augment UTP-induced Cl ion transport via hCLCA1 expression in a human bronchial epithelial cell line.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2007
Same author

Beta-adrenergic receptor-mediated growth of human airway epithelial cell lines.

The European respiratory journal·2002
Same author

[Effect of endothelin on DNA synthesis in human bronchial epithelium: role of MAP kinase cascade].

Arerugi = [Allergy]·2002

Asthma impairs mucociliary clearance, leading to airflow limitation. Increased mucus secretion from goblet cells, stimulated by histamine and leukotrienes, contributes to this impairment.

Area of Science:

  • Respiratory Physiology
  • Cell Biology
  • Immunology

Background:

  • Mucociliary transport is crucial for airway health, involving ciliary motility, airway surface fluid, and epithelial integrity.
  • Goblet cell hypersecretion and mucus plugs are observed in severe asthma, suggesting a role in respiratory obstruction.
  • Autonomic nerves and chemical mediators regulate goblet cell secretion, particularly in asthma.

Purpose of the Study:

  • To investigate the mechanisms underlying impaired mucociliary clearance in asthma.
  • To explore the role of goblet cell secretion and airway epithelial ion transport in asthma-related mucus production.

Main Methods:

  • Review of existing evidence on mucociliary function in asthma.
  • Analysis of factors influencing mucus glycoprotein and water secretion in airways.

Related Experiment Videos

  • Examination of the effects of histamine and leukotrienes on airway secretions.

    • Main Results:

    • Goblet cell hyperplasia and hypersecretion are linked to mucus plug formation in severe asthma.
    • Antigen challenge in sensitized animals increases mucus discharge, inhibited by histamine H2-receptor antagonists.
    • Histamine stimulates airway epithelial chloride and water secretion; leukotrienes may also increase mucus secretion.

    Conclusions:

    • Impaired mucociliary clearance is a significant factor in asthma-induced airflow limitation.
    • Goblet cell hypersecretion and altered airway epithelial ion transport are key contributors to mucus accumulation in asthma.
    • Further research is needed to fully elucidate the mechanisms, including the roles of bronchospasm and peptide leukotrienes.