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Should we aim at tissue renin-angiotensin systems?
J F Smits1, R C Passier, M J Daemen
1Department of Pharmacology, Cardiovascular Research Institute Maastricht (CARIM), Universiteit Maastricht, The Netherlands.
Pharmacy World & Science : PWS
|June 10, 1998
Summary
The renin-angiotensin system (RAS) has new findings regarding angiotensin II formation, receptors, and tissue functions. This review updates the classical RAS view and discusses its potential as a drug target for cardiovascular diseases.
Area of Science:
- Cardiovascular Science
- Endocrinology
- Pharmacology
Background:
- The classical view of the renin-angiotensin system (RAS) is being challenged by recent scientific discoveries.
- Understanding the RAS is crucial for managing cardiovascular diseases.
Purpose of the Study:
- To provide an updated perspective on the renin-angiotensin system.
- To discuss the implications of new RAS knowledge for drug development in cardiovascular disease.
Main Methods:
- Literature review of recent developments in RAS research.
- Analysis of novel findings on angiotensin II formation and metabolism.
- Examination of tissue-specific RAS components and functions.
Main Results:
- New pathways for angiotensin II formation and active metabolites have been identified.
- The diversity of RAS receptors and their biological functions are better understood.
- Renin-angiotensin systems are present in various tissues beyond the classical understanding.
Conclusions:
- The classical RAS model requires significant updates based on recent findings.
- Tissue-specific RAS components represent promising targets for novel cardiovascular therapies.
- Further research into tissue RAS is essential for advancing cardiovascular drug discovery.