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Related Experiment Videos

Hyperandrogenism in the adolescent female

V Toscano1, R Balducci, A Mangiantini

  • 1Dipartimento di Fisiopatologia Medica, Policlinico Umberto I, Università La Sapienza, Roma, Italy. i.s.g.s.h@agora.stm.it

Steroids
|June 10, 1998
PubMed
Summary

Precocious pubarche (PP) in girls increases the risk of developing adolescent hirsutism. Prepubertal hypertrichosis (PH) further elevates this risk. Early treatment for certain conditions like non-classical congenital adrenal hyperplasia (NC-CAH) can prevent hirsutism.

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Area of Science:

  • Pediatric Endocrinology
  • Reproductive Health
  • Androgen Excess Disorders

Background:

  • Hirsutism in adolescent girls often begins as an aesthetic concern and can lead to infertility and polycystic ovary syndrome due to prolonged hyperandrogenism.
  • Identifying early indicators of hirsutism is crucial for timely intervention and management of associated endocrine disorders.

Purpose of the Study:

  • To determine if specific prepubertal clinical signs can predict the development of hirsutism in adolescent girls.
  • To investigate the relationship between precocious pubarche (PP) and subsequent hirsutism, with or without prepubertal hypertrichosis (PH).

Main Methods:

  • Longitudinal follow-up of 70 girls with precocious pubarche (PP), with or without prepubertal hypertrichosis (PH), until 3 years post-menarche.
  • Retrospective analysis of 139 hirsute teenagers to assess the incidence of PP.

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  • Hormonal assays (testosterone, androstenedione, DHEAS, 17α-hydroxyprogesterone, LH, FSH) and pelvic ultrasonography were performed.

    • Main Results:

    • A history of PP was found in 21% of hirsute teenagers, significantly higher than the general population (0.6%).
    • Hirsutism developed in 63% of girls with PP; PH was present in 84% of these hirsute cases versus 35% of non-hirsute cases.
    • Non-classical congenital adrenal hyperplasia (NC-CAH) patients with PP had a higher incidence of hirsutism, but hydrocortisone treatment prevented its development.

    Conclusions:

    • Precocious pubarche (PP) is a significant risk factor for developing postpubertal hirsutism in adolescent girls.
    • The presence of prepubertal hypertrichosis (PH) alongside PP appears to further increase the likelihood of developing hirsutism.
    • Glucocorticoid therapy in NC-CAH patients effectively prevents hirsutism, suggesting potential benefits of early intervention in other PP cases.