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Neonatal necrotizing enterocolitis: the long-term perspective

J C Patel1, J J Tepas, S D Huffman

  • 1Department of Surgery, University of Florida Health Science Center Jacksonville 32209, USA.

The American Surgeon
|June 10, 1998
PubMed
Summary
This summary is machine-generated.

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Aggressive care for neonatal necrotizing enterocolitis (NNEC) surgery leads to good long-term survival. Most survivors of NNEC achieve a normal quality of life, making surgical intervention a worthwhile investment.

Area of Science:

  • Neonatal surgery
  • Pediatric gastroenterology
  • Critical care medicine

Background:

  • Neonatal necrotizing enterocolitis (NNEC) is a severe gastrointestinal emergency in premature infants.
  • Surgical intervention is often required for NNEC, but long-term outcomes and survival rates are critical considerations.

Purpose of the Study:

  • To evaluate long-term survival and quality of life in infants who underwent surgery for NNEC.
  • To identify risk factors associated with in-hospital mortality in NNEC patients.

Main Methods:

  • Retrospective review of 69 NNEC patients requiring surgery between 1986 and 1996.
  • Follow-up interviews with survivors' families to assess quality of life and persistent issues.
  • Comparison of long-term survivors (LTSs) with in-hospital deaths based on clinical parameters.

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Main Results:

  • The in-hospital mortality rate was 39.1%.
  • Of 58 eligible patients, 28 LTSs survived an average of 4.18 years.
  • 75% of LTSs achieved a normal quality of life; 6 had minor diarrhea, and 1 required a transplant.

Conclusions:

  • Aggressive in-hospital care and surgical intervention for NNEC are warranted.
  • The high rate of normal quality of life among survivors supports the value of intensive treatment for NNEC.
  • Birth weight, gestational age, and diagnosis timing were not significant predictors of mortality or survival outcomes.