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Advances in brain tumor chemosensitivity

C Balmaceda1

  • 1Division of Neuro-Oncology, Columbia-Presbyterian Medical Center, New York, NY 10032, USA.

Current Opinion in Oncology
|June 10, 1998
PubMed
Summary

Despite advances in cancer treatment, central nervous system tumors often recur. Understanding and overcoming chemotherapy drug resistance is crucial for developing effective brain tumor treatments and improving patient outcomes.

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Area of Science:

  • Neuro-oncology
  • Cancer chemotherapy
  • Pharmacology

Background:

  • Malignant central nervous system (CNS) tumors frequently recur despite current treatments like surgery and radiation.
  • Chemotherapy is a vital treatment modality for specific CNS tumors, including primary CNS lymphoma and oligodendrogliomas.
  • Overcoming drug resistance is essential for enhancing the efficacy of chemotherapy in brain tumor treatment.

Purpose of the Study:

  • To highlight the importance of understanding drug resistance in the design of clinical trials for CNS tumors.
  • To explore strategies for improving chemotherapy sensitivity in brain tumors.
  • To discuss the potential need for novel response assessment criteria in neuro-oncology.

Main Methods:

  • Literature review on chemotherapy resistance mechanisms in CNS tumors.
  • Analysis of potential strategies to enhance drug sensitivity.
  • Discussion of emerging concepts in treatment and response evaluation.

Main Results:

  • Chemotherapy plays a significant role in treating responsive CNS tumors.
  • Strategies to improve drug sensitivity include dose optimization, altered schedules, resistance modulators, and genetic manipulation.
  • Current response assessment criteria may require augmentation or replacement as therapies advance.

Conclusions:

  • Addressing and overcoming chemotherapy drug resistance is paramount for advancing CNS tumor treatment.
  • Innovative approaches to drug delivery, resistance modulation, and genetic modification hold promise.
  • Development of new response evaluation metrics is necessary to accurately assess treatment success in neuro-oncology.

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