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The human immunoglobulin lambda variable (IGLV) genes and joining (IGLJ) segments

N Pallarès1, J P Frippiat, V Giudicelli

  • 1Laboratoire d'ImmunoGénétique Moléculaire, CNRS, Université Montpellier II, France.

Experimental and Clinical Immunogenetics
|June 10, 1998
PubMed
Summary
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This study presents comprehensive tables detailing human germline immunoglobulin kappa variable (IGLV) and joining (IGLJ) genes and alleles. These resources are crucial for understanding the human immune system

Area of Science:

  • Immunogenetics
  • Genomics
  • Molecular Biology

Background:

  • The human immunoglobulin kappa locus (IGL) is critical for adaptive immunity.
  • Detailed characterization of germline IGLV and IGLJ genes and alleles is essential for immunogenetic research.

Purpose of the Study:

  • To provide a comprehensive catalog of human germline IGLV and IGLJ genes and their alleles.
  • To establish a foundational resource for the IMGT database, aiding in immunogenetic studies.

Main Methods:

  • Compilation and curation of data on human germline IGLV and IGLJ genes.
  • Organization of genetic information into five distinct tables for clarity and accessibility.

Main Results:

  • Publication of five detailed tables covering human germline IGLV and IGLJ gene numbers, repertoires, and alleles.

Related Experiment Videos

  • Data presented for the specific chromosomal location 22q11.1-q11.2 for IGLV genes.

    • Conclusions:

    • The presented tables offer a definitive resource for human IGLV and IGLJ genetic information.
    • These data are vital for researchers in immunogenetics, molecular biology, and genomics.