Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Porous polyglycolide

M Epple1, O Herzberg

  • 1Institute of Inorganic and Applied Chemistry, University of Hamburg, Germany. epple@xray.chemic.uni-hamburg.de

Journal of Biomedical Materials Research
|June 10, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhanced dissolution of silver nanoparticles (10 nm) in the presence of platinum nanoparticles (3 nm) causes increased cytotoxicity: mechanistic insight <i>via</i> transmission electron microscopy and X-ray powder diffraction.

RSC advances·2025
Same author

Barium sulphate microparticles are taken up by three different cell types: HeLa, THP-1, and hMSC.

Acta biomaterialia·2023
Same author

Tissue engineering at the dentin-pulp interface using human treated dentin scaffolds conditioned with DMP1 or BMP2 plasmid DNA-carrying calcium phosphate nanoparticles.

Acta biomaterialia·2023
Same author

X-ray powder diffraction to analyse bimetallic core-shell nanoparticles (gold and palladium; 7-8 nm).

RSC advances·2022
Same author

Covalent coupling of HIV-1 glycoprotein trimers to biodegradable calcium phosphate nanoparticles via genetically encoded aldehyde-tags.

Acta biomaterialia·2021
Same author

Cell-biological effects of zinc oxide spheres and rods from the nano- to the microscale at sub-toxic levels.

Cell biology and toxicology·2020

Solid-state polymerization of halogenoacetates yields porous polyglycolide (PGA). This biomaterial offers tunable properties like surface roughness and permeability for enhanced biocompatibility.

Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Materials Engineering

Background:

  • Polyglycolide (PGA) is a biodegradable polymer with significant potential in biomedical applications.
  • Conventional methods for PGA synthesis often result in materials lacking specific microstructural features.
  • Developing novel synthesis routes for advanced PGA materials is crucial for expanding their utility.

Purpose of the Study:

  • To investigate the solid-state polymerization of halogenoacetates for quantitative polyglycolide production.
  • To characterize the unique micromorphology and properties of the resulting porous polyglycolide.
  • To explore the potential of this porous polyglycolide as an advanced biomaterial.

Main Methods:

  • Solid-state polymerization of halogenoacetates.

Related Experiment Videos

  • Salt removal via washing to create porosity.
  • Characterization using Differential Scanning Calorimetry (DSC), Infrared (IR) spectroscopy, and X-ray diffraction (XRD).

    • Main Results:

    • Quantitative yield of polyglycolide (PGA) and metal halide.
    • Formation of highly porous PGA (approx. 50% pore volume) with submicron pores.
    • No residual halogenoacetate detected, confirmed by DSC, IR, and XRD.
    • Porous PGA exhibits inherent surface roughness, high specific surface area, increased gas permeability, and lower density compared to conventional PGA.

    Conclusions:

    • Solid-state polymerization offers a viable route to produce highly porous polyglycolide with controlled micromorphology.
    • The unique properties of this porous PGA are advantageous for biomaterial applications.
    • Tunable characteristics of porous PGA hold promise for fine-tuning biocompatibility and performance in biomedical devices.