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Autoimmune progesterone dermatitis and stomatitis

B K Moghadam1, S Hersini, B F Barker

  • 1Department of Diagnostic Sciences, University of Missouri-Kansas City School of Dentistry, 64108, USA.

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
|June 10, 1998
PubMed
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Autoimmune progesterone dermatitis causes cyclic skin and mucosal eruptions linked to the menstrual cycle. Treatment with tamoxifen, an antiestrogen, showed improvement by suppressing progesterone levels.

Area of Science:

  • Dermatology
  • Endocrinology
  • Immunology

Background:

  • Autoimmune progesterone dermatitis is a rare condition causing skin and mucosal eruptions.
  • Lesions are often exacerbated by hormonal fluctuations during the menstrual cycle.

Observation:

  • A patient presented with recurrent, cyclic lesions on the skin, oral mucosa, and lips.
  • These eruptions appeared pre-menstrually and persisted post-menstrually, resembling fixed drug eruptions.

Findings:

  • The condition is an autoimmune reaction to endogenous progesterone.
  • Conventional therapy with prednisone was ineffective.
  • Treatment with tamoxifen, an antiestrogen, led to clinical improvement.

Implications:

Related Experiment Videos

  • Tamoxifen's efficacy suggests a role for suppressing ovulation and progesterone levels in managing this condition.
  • This case highlights a potential therapeutic strategy for autoimmune progesterone dermatitis.
  • Further research into hormonal autoimmune disorders is warranted.