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Chronic verapamil modifies striatal and frontal cortex dopamine levels

M Sitges1, A Guarneros

  • 1Depto. de Biología Celular, Instituto de Investigaciones Biomédicas, Ciudad Universitaria, México, México DF. sitges@servidor.unam.mx

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
|June 10, 1998
PubMed
Summary

Verapamil

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Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Clinical studies suggest verapamil has antimanic effects.
  • The role of dopamine (DA) in verapamil's antimanic action requires elucidation.
  • Verapamil's impact on monoamine concentrations in specific brain regions is not fully understood.

Purpose of the Study:

  • To investigate if changes in dopamine levels mediate verapamil's antimanic effects.
  • To compare the effects of chronic verapamil and haloperidol on monoamine concentrations in rat brain regions.
  • To explore the involvement of dopamine autoreceptors in verapamil's neurochemical actions.

Main Methods:

  • Quantification of monoamine concentrations in rat striatum, frontal cortex, and hippocampus using HPLC with electrochemical detection.
  • Comparison between rats treated chronically (21 days) with verapamil (10 mg/kg) or haloperidol (5 mg/kg).
  • Assessment of acute (single injection) and chronic effects of drug administration.

Main Results:

  • Chronic verapamil and haloperidol similarly decreased striatal dopamine (DA) concentrations after 21 days.
  • Acute verapamil administration increased striatal DA, while chronic treatment decreased it.
  • Chronic verapamil increased frontal cortex DA, whereas haloperidol increased striatal DOPAC, suggesting differential effects and receptor involvement.

Conclusions:

  • Dopamine autoreceptors are implicated in verapamil's long-term effects on dopamine levels in the striatum and frontal cortex.
  • The antimanic action of verapamil may be attributed to its chronic influence on these dopamine autoreceptors.
  • Verapamil's neurochemical effects differ from haloperidol, particularly in acute administration and metabolite changes.

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