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Chirality of reduced haloperidol in humans
D W Eyles1, J J McGrath, T J Stedman
1Queensland Centre for Schizophrenia Research, Wolston Park Hospital, Wacol, Brisbane, Australia.
Abstract:
In vitro, cytosolic human ketone reductases catalyse the stereospecific (i.e. >99%) formation of S(-) reduced haloperidol (RHP) from haloperidol (HP). Whether this situation is reflected in patients taking the drug is unknown. In this study in nine patients taking HP, only 73.2+/-18.2% of the RHP excreted in urine was the S(-) enantiomer. Thus, enzymes other than cytosolic ketone reductases must be responsible for the formation of the minor enantiomer.