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Experience with diffusion-weighted imaging in an acute stroke unit

S J Read1, G D Jackson, D F Abbott

  • 1Department of Medicine (Neurology), Centre for Brain Imaging Research, University of Melbourne and Austin and Repatriation Medical Centre, Australia.

Cerebrovascular Diseases (Basel, Switzerland)
|June 10, 1998
PubMed
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Diffusion-weighted MRI (DWI) aids in early ischemic stroke diagnosis. This technique detects cerebral ischemia within hours of stroke onset, even when CT and T2-weighted MRI are normal.

Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Ischemic stroke diagnosis requires timely detection for effective therapy.
  • Conventional MRI sequences (CT, T2-weighted) may not detect early ischemic changes.
  • Diffusion-weighted MRI (DWI) offers potential for earlier detection.

Purpose of the Study:

  • To evaluate the clinical utility of DWI for early ischemic stroke diagnosis.
  • To assess if DWI can identify cerebral ischemia within the therapeutic time window.
  • To compare DWI findings with conventional MRI and CT in stroke patients.

Main Methods:

  • Diffusion-weighted MRI (DWI) using a turboSTEAM sequence on a 1.5-tesla scanner.
  • Study included 9 acute ischemic stroke patients and 9 healthy controls.

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  • DWI scans were performed between 3.75 hours and 3 days post-stroke onset.

    • Main Results:

    • DWI scans were normal in all 9 control subjects.
    • Seven out of 9 stroke patients showed increased signal intensity on DWI, indicating ischemia.
    • DWI detected cerebral ischemia as early as 3.75 hours post-stroke, when CT and T2-weighted MRI were normal.

    Conclusions:

    • DWI on standard MRI systems provides valuable information for stroke assessment.
    • DWI facilitates the early detection of cerebral ischemia, crucial for timely therapeutic intervention.
    • DWI enhances diagnostic capabilities beyond conventional MRI sequences in acute stroke cases.