Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Frontoethmoidal encephaloceles, a study of their pathogenesis

E W Hoving1, C Vermeij-Keers

  • 1Department of Neurosurgery, University Hospital Groningen, The Netherlands. e.w.hoving@med.rug.nl

Pediatric Neurosurgery
|June 10, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of centralized care on the management of postoperative fluctuations in plasma sodium concentration after pediatric suprasellar brain tumor surgery.

Pituitary·2026
Same author

BMI trajectories in the first 3 months after childhood craniopharyngioma resection: a plea for early management of BMI changes.

Endocrine connections·2025
Same author

T2-FLAIR Mismatch: An Imaging Biomarker for Children's <i>MYB/MYBL1</i>-Altered Diffuse Astrocytoma or Angiocentric Glioma.

AJNR. American journal of neuroradiology·2024
Same author

Ultra-fast deep-learned CNS tumour classification during surgery.

Nature·2023
Same author

Radiosensitisation by olaparib through focused ultrasound delivery in a diffuse midline glioma model.

Journal of controlled release : official journal of the Controlled Release Society·2023
Same author

Resting energy expenditure in children at risk of hypothalamic dysfunction.

Endocrine connections·2022

Frontoethmoidal encephaloceles may stem from a failure in neural and surface ectoderm separation during early gestation. This developmental disturbance leads to midline skull defects and herniation of brain tissue.

Area of Science:

  • Developmental biology
  • Neuroscience
  • Clinical medicine

Background:

  • Frontoethmoidal encephalocele is a congenital condition.
  • Previous embryological studies suggest a link to neurulation defects.

Purpose of the Study:

  • To investigate the pathogenesis of frontoethmoidal encephaloceles.
  • To support a theory of abnormal ectoderm separation during neurulation.

Main Methods:

  • Prospective clinical study of 30 patients.
  • Clinical examination, radiological imaging (X-skull, CT scans).
  • Histological examination of surgical specimens.

Main Results:

  • Consistent location of internal skull defects.

Related Experiment Videos

  • Epidermal and glial tissue proximity observed in 15/29 specimens.
  • Normal nasal development with interorbital hypertelorism in all patients.

    • Conclusions:

    • Findings support the theory of disrupted neural and surface ectoderm separation.
    • Abnormal apoptosis may cause this separation defect.
    • Secondary mesodermal defects contribute to encephalocele formation.