Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Corpus callosotomy for medically intractable seizures

J M Sorenson1, J W Wheless, J E Baumgartner

  • 1Department of Neurology, Texas Comprehensive Epilepsy Program, University of Texas, Houston 77225-0708, USA.

Pediatric Neurosurgery
|June 10, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiple Intussusceptions Associated with Polycythemia in an Anabolic Steroid Abuser, A Case Report and Literature Review.

Annals of medical and health sciences research·2015
Same author

Cortical Activation Through Passive-Motion Functional MRI.

AJNR. American journal of neuroradiology·2015
Same author

Evolution of diagnostic criteria in psychoses.

Dialogues in clinical neuroscience·2011
Same author

Observations on Venous Pressure, Particularly in the Presence of Arterial Hypertension.

Transactions of the American Climatological and Clinical Association. American Climatological and Clinical Association·2011
Same author

Hippocampal gene network analysis in an experimental model of posttraumatic epilepsy.

Neurochemical research·2010
Same author

Simultaneous estimation of Montelukast sodium and Bambuterol hydrochloride in tablets by spectrophotometry.

Hindustan antibiotics bulletin·2009

Corpus callosotomy can significantly reduce seizure frequency in patients with intractable epilepsy. A normal preoperative MRI is the best predictor of a good outcome, while intellectual disability is associated with poorer results.

Area of Science:

  • Neurosurgery
  • Epileptology
  • Neurology

Background:

  • Intractable generalized seizures pose significant challenges in patient management.
  • Corpus callosotomy is a surgical option for epilepsy refractory to medical treatment.

Purpose of the Study:

  • To identify factors influencing outcome and morbidity in patients undergoing corpus callosotomy.
  • To evaluate the effectiveness of corpus callosotomy in reducing seizure frequency and severity.

Main Methods:

  • Retrospective review of 23 patients with intractable generalized seizures who underwent corpus callosotomy between 1991 and 1994.
  • Analysis of preoperative factors, surgical extent (complete vs. anterior callosotomy), and postoperative outcomes.

Main Results:

Related Experiment Videos

  • 41% of patients were nearly or completely seizure-free; 45% experienced >50% seizure reduction.
  • A normal preoperative MRI was the strongest predictor of a favorable outcome.
  • Mentally retarded patients had poorer outcomes; extent of callosal section did not predict outcome.
  • Completion of anterior callosotomy led to significant seizure frequency reduction.
  • Transient disconnection syndrome occurred in 57% of patients.

Conclusions:

  • Corpus callosotomy can achieve worthwhile palliation for intractable epilepsy, though complete seizure freedom is uncommon.
  • Patient selection is crucial, with normal preoperative MRI and absence of intellectual disability favoring better outcomes.
  • Further analysis of prognostic factors can optimize patient selection for corpus callosotomy.