A double-blind study comparing two single-dose regimens of ketorolac with diclofenac in pain due to cancer
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V Minotti1, M Betti, G Ciccarese
1Division of Medical Oncology, Perugia Hospital, Italy.
Study Objective:
To compare the analgesic efficacy and safety of two single doses of ketorolac with diclofenac in acute cancer pain.
Design:
Double-blind, randomized, clinical study.
Setting:
Hospital-based clinical research center.
Subjects:
One hundred eighty patients suffering acute, moderate, or severe cancer pain.
Interventions:
A single intramuscular injection of ketorolac 10 or 30 mg or diclofenac 75 mg.
Measurements And Main Results:
Pain intensity was assessed 30 minutes and 1, 2, 3, 4, 5, and 6 hours after injection or until rescue drug administration. In approximately 70% of patients all treatments provided prompt sustained pain relief throughout the 6-hour observation period. There were no statistically significant differences in any of the analyzed efficacy measures among the three groups.
Conclusion:
Intramuscular ketorolac 10 mg is adequate to relieve cancer pain, and is equivalent to ketorolac 30 mg and to diclofenac 75 mg.