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Updated: Oct 15, 2026
08:43
Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
An efficient and convenient procedure for the synthesis of N(alpha)-Fmoc-O-monobenzyl phosphonotyrosine
1Physical Methods Department, Roche Discovery Welwyn, Welwyn Garden City, Hertfordshire, UK.
Abstract:
An efficient procedure is described for the synthesis of N(alpha)-Fmoc-O-monobenzyl phosphonotyrosine from the corresponding dibenzyl derivative by monodebenzylation in the presence of sodium iodide. A simple work up procedure removes the by-products and the monobenzylated phosphono product is obtained in high yield.
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