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Synthesis and antimicrobial activity of pyridines bearing thiazoline and thiazolidinone moieties
H Y Hassan1, N A el-Koussi, Z S Farghaly
1Pharmaceutical Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University, Egypt.
Chemical & Pharmaceutical Bulletin
|June 11, 1998
Abstract:
Two series of new pyridines bearing thiazoline (3a--n) and thiazolidinone (5a--e) moieties were prepared via the cyclization of the corresponding substituted pyridyl thiourea (2a--g) with an appropriately substituted phenacyl bromide or chloroacetic acid, respectively. The antimicrobial activity was determined for representative compounds and most of them showed moderate activity against Gram-positive bacteria.