Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

True malignant histiocytosis

W Mongkonsritragoon1, C Y Li, R L Phyliky

  • 1Division of Hematopathology, Mayo Clinic Rochester, Minnesota 55905, USA.

Mayo Clinic Proceedings
|June 11, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Management of early bronchopleural fistula after pneumonectomy].

Zhonghua yi xue za zhi·2016
Same author

[Exploratory and confirmatory factor analyses for testing validity and reliability of the Chinese language questionnaire for urinary incontinence diagnosis].

Zhonghua fu chan ke za zhi·2016
Same author

The Effect Of Atriala Fibrillation In Acute Myocardial Infarction Patients In Taiwan.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2016
Same author

[One case of newly-onset liver cancer and dual drug-resistance during treatment of hepatitis B cirrhosis with nucleos(t)ide analogues].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology·2016
Same author

5-Fluorouracil induces apoptosis of colorectal cancer cells.

Genetics and molecular research : GMR·2016
Same author

Doubly Q-switched Ho:LuAG laser with acoustic-optic modulator and Cr²⁺:ZnS saturable absorber.

Applied optics·2016
Same journal

Advancing Pulmonary Fibrosis Care: Integrating Genomic Insights Into Clinical Practice.

Mayo Clinic proceedings·2026
Same journal

RAAS Inhibition in the ICU: Stop, Continue, or Restart?

Mayo Clinic proceedings·2026
Same journal

Chronic Kidney Disease-In the Limelight, July 2026.

Mayo Clinic proceedings·2026
Same journal

In Reply: Long-Term Cardiovascular Burden After Carotid Endarterectomy: Moving Beyond Conventional Risk Profiling.

Mayo Clinic proceedings·2026
Same journal

Long-Term Cardiovascular Burden After Carotid Endarterectomy: Moving Beyond Conventional Risk Profiling.

Mayo Clinic proceedings·2026
Same journal

Real-World Comparative Effectiveness of Tirzepatide and Semaglutide for Obesity: A Multicentered Study.

Mayo Clinic proceedings·2026
See all related articles

True malignant histiocytosis is rare, with most cases misdiagnosed. Recent methods confirm only one of seven studied cases was truly histiocytic, highlighting diagnostic challenges in hematologic malignancies.

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Malignant histiocytosis is a poorly understood group of disorders.
  • Distinguishing true malignant histiocytosis from similar clinical syndromes is challenging.
  • Previous diagnostic limitations hindered accurate classification.

Purpose of the Study:

  • To differentiate true malignant histiocytosis from clinical syndromes using modern techniques.
  • To re-evaluate cases previously diagnosed as malignant histiocytosis.
  • To clarify the cellular origin of malignant cells in these syndromes.

Main Methods:

  • Retrospective analysis of clinical data and laboratory findings.
  • Review of paraffin-embedded tissue specimens.
  • Application of advanced morphologic, cytochemical, immunohistochemical, cytogenetic, and molecular genetic studies.

Related Experiment Videos

Main Results:

  • Only one of seven cases exhibited a true histiocytic origin.
  • Malignant cells were identified as T cells in three cases (two CD30+).
  • Other cases involved CD30+ cells, epithelial cells, or undetermined cell types.

Conclusions:

  • True malignant histiocytosis is exceptionally rare.
  • Modern diagnostic techniques are crucial for accurate identification.
  • Newer methods enable precise characterization of malignant cells, overcoming previous limitations.