Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human prostate carcinogenesis

J S Rhim1, H F Kung

  • 1Laboratory of Biochemical Physiology, National Cancer Institute, Frederick, Maryland 21702, USA.

Critical Reviews in Oncogenesis
|January 1, 1997
PubMed
Summary

Developing in vitro models for prostate cancer is crucial for understanding its development. Researchers have successfully achieved stepwise neoplastic transformation of human prostate epithelial cells, paving the way for further study.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential gene expression profile of CD4+/CD8+ T cells in patients with hepatitis C virus and/or human immunodeficiency virus infection.

Hong Kong medical journal = Xianggang yi xue za zhi·2016
Same author

Decreased expression of H3K27me3 in human ovarian carcinomas correlates with more aggressive tumor behavior and poor patient survival.

Neoplasma·2015
Same author

MiR-29c mediates epithelial-to-mesenchymal transition in human colorectal carcinoma metastasis via PTP4A and GNA13 regulation of β-catenin signaling.

Annals of oncology : official journal of the European Society for Medical Oncology·2014
Same author

Oncogenic miR-20a and miR-106a enhance the invasiveness of human glioma stem cells by directly targeting TIMP-2.

Oncogene·2014
Same author

HGFK1 inhibits bone metastasis in breast cancer through the TAK1/p38 MAPK signaling pathway.

Cancer gene therapy·2012
Same author

Localization of 5-HT1A and 5-HT2A positive cells in the brainstems of control age-matched and Alzheimer individuals.

Age (Dordrecht, Netherlands)·2010

Area of Science:

  • Oncology
  • Cell Biology
  • Molecular Biology

Background:

  • Prostate cancer is a significant health concern with poorly understood etiological mechanisms.
  • Difficulties in diagnosis and treatment, coupled with limited research materials, hinder progress in understanding prostate carcinogenesis.
  • There is an urgent need for in vitro human cell models to study prostate cancer progression.

Purpose of the Study:

  • To review the steps involved in the neoplastic transformation of human prostate cells.
  • To provide insight into the molecular and genetic mechanisms of prostate cancer development.
  • To discuss the current state-of-the-art in transforming human prostate epithelial cells in culture.

Main Methods:

  • Review of existing literature on human prostate epithelial cell transformation.
  • Discussion of stepwise neoplastic transformation: immortalization and tumorigenic conversion.
  • Analysis of carcinogenic agents and their role in cell transformation.

Main Results:

  • Successful stepwise neoplastic transformation of human prostate epithelial cells in culture has been achieved.
  • Immortalization of primary cells followed by conversion to a tumorigenic state is a viable approach.
  • This provides a practical system for studying prostate cancer progression.

Conclusions:

  • The development of in vitro models is essential for advancing the understanding of prostate cancer.
  • Stepwise neoplastic transformation offers a pathway to study the molecular and genetic basis of prostate tumorigenesis.
  • Further research using these models will elucidate mechanisms of prostate cancer development.

Related Experiment Videos