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Related Experiment Videos

Heparin cofactor II: a new marker for pre-eclampsia

J Bellart1, R Gilabert, L Cabero

  • 1Unitat de Medicina Materno-fetal, Hospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili, Spain. jbellarta@meditex.es

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|June 11, 1998
PubMed
Summary

Plasma levels of heparin cofactor II were lower in pregnant women with pre-eclampsia. This finding may help differentiate pre-eclampsia from other hypertensive disorders in pregnancy.

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Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Cardiovascular Physiology

Background:

  • Hypertensive disorders in pregnancy, including pre-eclampsia, pose significant risks.
  • Accurate differential diagnosis between various hypertensive conditions is crucial for appropriate management.
  • Heparin cofactor II (HC-II) is a key regulator of thrombin generation.

Purpose of the Study:

  • To investigate plasma levels of heparin cofactor II (HC-II) in pregnant women with different hypertensive conditions.
  • To assess the potential of HC-II levels in differentiating pre-eclampsia from other forms of hypertension during pregnancy.

Main Methods:

  • Plasma samples were collected from pregnant women in their third trimester and 72 hours postpartum.
  • Participants were categorized into normotensive, essential hypertension, gestational hypertension, and pre-eclampsia groups.

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  • Plasma concentrations of heparin cofactor II were measured using established biochemical assays.

    • Main Results:

    • A significant depression in plasma heparin cofactor II levels was observed in the pre-eclampsia group compared to normotensive and other hypertensive groups.
    • No significant differences in HC-II levels were noted between normotensive, essential hypertension, and gestational hypertension groups.

    Conclusions:

    • Reduced plasma heparin cofactor II levels are associated with pre-eclampsia during late pregnancy.
    • Plasma HC-II levels may serve as a useful biomarker for the differential diagnosis of non-proteinuric hypertension versus pre-eclampsia.