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Urinary albumin excretion and heart rate variability in obese women
B Andersson1, J Wikstrand, T Ljung
1Department of Medicine, Sahlgrenska University Hospital, Göteborg University, Sweden.
Objective:
The aim of this work was to examine the relationship between cardiac autonomic function and urinary albumin excretion in obesity.
Subjects:
These were 27 obese non-diabetic postmenopausal women and 18 non-obese healthy postmenopausal women.
Measurements:
Urinary albumin excretion as well as plasma nitrate, both indices of capillary function, were measured. Power spectral analysis of heart rate variability was performed, as a measurement of vagal function. An oral glucose tolerance test (OGTT) was performed and blood lipids were analysed.
Results:
The obese women were characterized by higher fasting insulin, sum of glucose, triglycerides and lower high density lipoprotein cholesterol (HDL), the latter of borderline significance, than controls. Urinary albumin excretion (UAE), plasma nitrate and heart rate variability were not different between obese and control women. However, in obese women log UAE correlated positively with systolic and diastolic blood pressure, and inversely with heart rate variability, the latter independent of body mass index (BMI) and the waist/hip circumference ratio.
Conclusion:
It was concluded that this inverse association between UAE and parasympathetic activity in obese women may be an early sign of derangements of endothelial function and autonomic nervous system control, which may contribute to the increased risk of cardiovascular mortality in abdominal obesity.