Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transient c-fos gene expression in cerebellar development and functional stimulation

S Chen1, Y Q Ren, G Y Bing

  • 1Departments of Otolaryngology and Physiology/Neuroscience, New York University Medical Center, 550 1st Avenue, New York, NY 10016, USA.

Brain Research
|June 12, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neurotrimin expression during cerebellar development suggests roles in axon fasciculation and synaptogenesis.

Journal of neurocytology·2002
Same author

Alpha 1E subunit of the R-type calcium channel is associated with myelinogenesis.

Journal of neurocytology·2001
Same author

Dying-back of Purkinje cell dendrites with synapse loss in aging rats.

Journal of neurocytology·2000
Same author

c-fos gene expression parallels auditory adaptation in the adult rat.

Brain research·1999
Same author

Activation of fos in mouse amygdala by local infusion of norepinephrine or atipamezole.

Brain research·1998
Same author

Distribution of glutamate receptors GluR 2/3 and NR1 in the developing rat cerebellum.

Neuroscience·1997

C-fos expression in rat cerebellum is transient during development and rapidly re-induced in adults by glutamate agonists. This gene

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Developmental Biology

Background:

  • C-fos gene expression is a marker for neuronal activity.
  • Understanding c-fos temporal dynamics is crucial for studying cerebellar development and function.

Purpose of the Study:

  • To investigate the temporal patterns of c-fos expression in rat cerebellum during postnatal development.
  • To examine c-fos induction in adult rat cerebellum following kainic acid administration and cerebellar lesioning.

Main Methods:

  • Immunohistochemistry to detect Fos protein in rat cerebellar tissues.
  • Systemic kainic acid injection and unilateral cerebellar lesioning in adult rats.

Main Results:

  • During development, c-fos expression in granule cells peaks around postnatal day 15 and declines by adulthood.

Related Experiment Videos

  • Kainic acid rapidly induces c-fos in adult cerebellar granule cells and interneurons.
  • Combined kainic acid and lesioning enhances c-fos expression ipsilaterally, including in Purkinje cell nuclei.

    • Conclusions:

    • C-fos expression is transient in developing cerebellar granule cells and can be quickly reactivated in adults.
    • C-fos patterns suggest clustered granule cell subpopulations relate to parasagittal Purkinje cell compartments.