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Low grade cervical intraepithelial neoplasia associated with human papillomavirus infection. Long-term follow-up
Y Matsuura1, T Kawagoe, N Toki
1Department of Obstetrics and Gynecology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Objective:
To investigate the correlation between the development of low grade cervical intraepithelial neoplasia (LCIN) and human papillomavirus (HPV) infection in cases with long-term follow-up.
Study Design:
Forty-three cases of LCIN were followed for more than five years with cytology, colposcopy and Vira Pap. Coexistence of HPV infection was sought using a simplified HPV detection kit, the Vira Pap method (Dot Blot hybridization).
Results:
Regressive disease was noted in 21 cases, and persistent and progressive disease was noted in 22 cases. HPV DNA was negative in 81% (17 of 21) of regressive disease and positive in 55% (12 of 22) persistent and progressive disease. LCIN had disappeared in 17 (63%) of 27 cases negative for HPV DNA and was persistent or progressive in 12 (75%) of 16 cases positive for HPV DNA.
Conclusion:
The clinical course of LCIN correlates well with HPV infection.