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[Phyllodes tumor in the breast]
D I Vos1, W J Mastboom, R A de Vos
1Medisch Spectrum Twente, afd. Heelkunde, Enschede.
Nederlands Tijdschrift Voor Geneeskunde
|June 12, 1998
Summary
Phyllodes tumors are rare breast tumors affecting women aged 30-50. Radical surgical excision with clear margins is the recommended treatment to prevent recurrence.
Area of Science:
- Oncology
- Pathology
- Surgical Oncology
Background:
- Phyllodes tumors are rare breast neoplasms with unpredictable clinical behavior.
- They typically present as large, rapidly growing masses in women aged 30-50.
- Diagnostic imaging and cytology often provide limited information due to tumor heterogeneity.
Observation:
- Three cases of phyllodes tumors in women aged 37, 51, and 58 are presented.
- Patients underwent radical surgical excision.
- One patient received adjuvant radiotherapy.
Findings:
- No recurrences were observed during 3-5 years of follow-up.
- Histological assessment is crucial for grading (benign, borderline, malignant) and prognosis.
- Key prognostic factors include atypia, mitotic activity, and stromal overgrowth.
Implications:
- Wide surgical excision (≥1 cm margin) is the treatment of choice for phyllodes tumors.
- Incomplete excision carries a significant risk of recurrence and potential malignant transformation.
- Close collaboration between surgeons and pathologists is essential for accurate diagnosis, prognosis, and treatment planning.