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[Phyllodes tumor in the breast]

D I Vos1, W J Mastboom, R A de Vos

  • 1Medisch Spectrum Twente, afd. Heelkunde, Enschede.

Nederlands Tijdschrift Voor Geneeskunde
|June 12, 1998
PubMed
Summary
This summary is machine-generated.

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Phyllodes tumors are rare breast tumors affecting women aged 30-50. Radical surgical excision with clear margins is the recommended treatment to prevent recurrence.

Area of Science:

  • Oncology
  • Pathology
  • Surgical Oncology

Background:

  • Phyllodes tumors are rare breast neoplasms with unpredictable clinical behavior.
  • They typically present as large, rapidly growing masses in women aged 30-50.
  • Diagnostic imaging and cytology often provide limited information due to tumor heterogeneity.

Observation:

  • Three cases of phyllodes tumors in women aged 37, 51, and 58 are presented.
  • Patients underwent radical surgical excision.
  • One patient received adjuvant radiotherapy.

Findings:

  • No recurrences were observed during 3-5 years of follow-up.
  • Histological assessment is crucial for grading (benign, borderline, malignant) and prognosis.
  • Key prognostic factors include atypia, mitotic activity, and stromal overgrowth.

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Implications:

  • Wide surgical excision (≥1 cm margin) is the treatment of choice for phyllodes tumors.
  • Incomplete excision carries a significant risk of recurrence and potential malignant transformation.
  • Close collaboration between surgeons and pathologists is essential for accurate diagnosis, prognosis, and treatment planning.